Board Case Study · Biotech (CAR-T) · Hypothetical
The platform was built on open-science CRISPR research that belongs to the world. If the AI designs the breakthrough therapy, who owns it? The next financing round is waiting on the answer.
The situation
HelixImmune Therapeutics is a CRISPR-derived CAR-T platform spun out of an open-science research institute, using AI to optimize personalized T-cell receptor engineering for blood cancers and solid tumors. It is pre-revenue, running on $680M in philanthropic and NIH grants at a ~$75M annual burn, with Phase 1 complete and three letters of intent from major pharma.
The platform's foundation is open science, research that, by design, belongs to the world. But investors want defensible, licensable IP, and academics expect open publication. With 200-plus overlapping CRISPR patents in the field, freedom-to-operate risk is material, and the AI-selected CAR constructs lack the validation trail the FDA requires for biologics filings.
No board-level AI oversight committee exists, the foundation model's training-data provenance is incomplete, and outside counsel has already flagged infringement risk from AI-generated outputs. All of it has to be resolved before the next financing round. (A hypothetical case, for educational use only.)
“Our platform was built on open science, CRISPR research that belongs to the world. If our AI designs the breakthrough, who owns it?”
Dr. Maya Osei · CEO & Co-Founder (hypothetical)
The decision on the table
The full case, scenario architecture, board materials, and facilitation notes, is shared with boards and partners on request.